Proteins MOVE!
A first look at nanosecond protein domain dynamics HERE!
Protein nanomachines are far more complex than any
molecular machines that have yet been artificially constructed.
Their skillful utilization likely represents the future of medicine.
Contact us
HERE
Neutron spin echo spectroscopy (NSE) is the only experimental technique that can determine protein motion on nano length scales and on nanosecond to microsecond time scales. NSE can reveal protein domain motions in a protein or within a protein complex on length-scales comparable to their overall dimension. Such motions have long been hypothesized to be the most significant modes for protein function. We have developed a theoretical framework that allows one to interpret the NSE data
★Easy introduction to NSE HERE★
Nanoscale
protein dynamics:
A new
frontier
for neutron spin echo spectroscopy
Our theoretical framework uses simple concepts from
nonequilibrium statistical mechanics, and does not require
elaborate molecular dynamics simulations, complex fits to
rotational motion, or elastic network models. In combination
with our experimental methodology of selective deuterium
labeling, our work clears significant hurdles to the
understanding of this very important problem.
Can you express and purify proteins? FPLC? We need you!
Want a PhD? Looking for a summer internship? Students and postdocs wanted!
欢迎访问学者客座教授
Numerous
well-compensated
positions
are available, at ALL levels.
Apply
HERE for jobs
Visiting scholars and professors welcome!
Contact us
HERE
We use X-ray and neutron scattering
to
probe protein structure and dynamics
in novel ways.
We do what no one else can.
Positions require expertise
in protein biochemistry,
molecular and
cell biology, and physical chemistry.
Protein expression and purification by fast protein liquid chromatography (FPLC)
is necessary.
Useful skills also include
isothermal titration calorimetry (ITC),
microscale thermophoresis (MST), biolayer interferometry (BLI).
protein NMR, restriction enzyme digest, molecular cloning, transformation, DNA sequencing, peptide design,
DNA and RNA isolation, PCR, RT-PCR,
Random Amplified cDNA Ends (RACE), Southern and northern analyses,
SDS-PAGE, western analysis, isotopic and radioactive labeling, enzyme assays, ELISA and gel electrophoresis.
Dynamic light scattering, analytical ultracentrifugation, velocity sedimentation, surface plasmon resonance.
Extremely well-funded, international travel likely.
Enthusiastic and innovative scientists
who can work
independently
are
encouraged to apply.
★ 在纽约市的高薪职位 ★
★ 欢迎访问学者和客座教授 ★
★ 纽约市曼哈顿 ★
★ 生物化学 ★ 蛋白质化学 ★
★ 结构生物学 ★ 生物物理学 ★
Above-average
compensation
available for exceptional
individuals
Are you looking for a Senior Associate Scientist or Protein Engineering position?
Are you an FPLC expert?
Visiting scholars and professors welcome!
Numerous
well-paid
positions
are available, at ALL levels.
Can you express and purify proteins? FPLC? We need you!
Contact us
HERE!
APPLY NOW!